Preparation and Antimicrobial Evaluation of N'-arylidene-3-(4-phenyloxazol-2 yl)propanehydrazides

Construction of a series of N'-arylidene-3-(4-phenyloxazol-2-yl)propanehydrazide 4a–4j was achieved through the development of an easy, effective, and environmentally safe method. Under moderate reaction conditions, each substrate was obtained in good yield. IR, 1H NMR, 13C NMR, and mass analysis were used to characterize each prepared hydrazone. Moreover, an antimicrobial activity screen was conducted on compounds 4a–4j. The prepared compounds' anti-microbial properties were tested against four bacterial strains Bacillus cereus, Bacillus megaterium, Escherichia coli, Xanthomonas campestris, and Candida albicans. Compounds 4i, 4f, and 4a demonstrated superior activity against Xanthomonas campestris, the compounds 4j, 4a, and 4h demonstrated good activity against Bacillus megaterium, the compounds 4a–4j display moderate activity against Escherichia coli, and Candida albicans.